SECTION 1 – PHYTOCHEMISTRY, ECOLOGY AND DIVERSITY

Application of Matrix Solid-Phase Dispersion for HPLC analysis of polyphenol profile in 50-years old herbarium specimens of Polygonum aviculare L.
Krzysztof Kapelańczyk1, Sandra Niezgoda1, Weronika Kozłowska2, Sylwester Ślusarczyk2, Anna Prescha3, Adam Matkowski*2,4
1Student Scientific Association, Department of Pharmaceutical Biology, Wroclaw Medical University
2Department of Pharmaceutical Biology and Botany, Wroclaw Medical University, Wrocław, Poland
3Department of Food Science and Nutrition, Wroclaw Medical University, Wrocław, Poland
4Laboratory of Experimental Cultivation of Herbs, Botanical Garden of Medicinal Plants, Wroclaw Medical University, Wrocław, Poland

Phenolic compounds and antioxidant capacity of plum fruits of cv “Čačanska Lepotica” grown on different rootstocks
Viktoria Ivanova*1, Boryana Trusheva1, Sava Tabakov2, Antoaneta Trendafilova1
1Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., bl. 9, 1113 Sofia, Bulgaria
2Agricultural University, Department of Fruit Growing, Mendeleev Bld., 12, 4000 Plovdiv, Bulgaria

Chemotype Determination of German Chamomile (Matricaria recutita L.) in Ukraine
Ivan Salamon*1, Maryna Kryvtsova2, Miroslava Hrytsyna3
1Department of Ecology, Faculty of Humanities and Natural Sciences, University of Presov, 01, 17th November St., SK-081 01 Presov, Slovakia
2Department of Genetics, Plant Physiology and Microbiology, Biological Faculty, Uzhhorod National University,  Biological Faculty,  32, Voloshyn St., UA-88000, Uzhhorod, Ukraine
3Department of Pharmacy and Biology, Faculty of Veterinary Hygiene, Ecology and Law, Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies, 55, Pekarská St., UA-79040  Lviv, Ukraine

AFLP vs SSR markers in population genetic studies: Genetic diversity of Dalmatian sage (Salvia officinalis L.)
Zlatko Šatović*1,2, Filip Varga1,2, Marija Jug-Dujaković3, Martina Grdiša1,2, Tonka Ninčević3, Klaudija Carović-Stanko1,2, Zlatko Liber2,4
1University of Zagreb, Faculty of Agriculture, Svetošimunska cesta 25, 10000 Zagreb
2Centre of Excellence for Biodiversity and Molecular Plant Breeding (CoE CroP-BioDiv), Svetošimunska cesta 25, 10000 Zagreb, Croatia
3Institute for Adriatic Crops and Karst Reclamation, Put Duilova 11, 21000 Split, Croatia
4University of Zagreb, Faculty of Science, Marulićev trg 9a, 10000 Zagreb

Composition and content of pyrethrin in different flower development stages of Dalmatian pyrethrum
Filip Varga*1,2, Martina Biošić3, Dario Dabić3, Zlatko Šatović1,2, Martina Grdiša1,2
1University of Zagreb Faculty of Agriculture, Department of Seed Science and Technology, Svetošimunska cesta 25, 10000, Zagreb, Croatia
2Centre of Excellence for Biodiversity and Molecular Plant Breeding, Svetošimunska cesta 25, 10000, Zagreb, Croatia
3Department of Analytical Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, 10000 Zagreb, Croatia

Biochemical diversity of Immortelle (Helichrysum italicum /Roth./G. Don) populations in Croatia
Tonka Ninčević Runjić*1, Dejan Pljevljakušić2, Martina Grdiša3,4, Marija Jug-Dujaković1, Marko Runjić1, Filip Varga3,4, Zlatko Šatović3,4
1Institute for Adriatic Crops and Karst Reclamation, Put Duilova 11, 21000, Split, Croatia
2Institute for the Study of Medicinal Plants „Josif Pančić“, Tadeuša Koščuška 1, Beograd, Serbia
3University of Zagreb, Faculty of Agriculture, Department of Seed Science and Technology, Svetošimunska cesta 25, 10000 Zagreb, Croatia
4Centre of Excellence for Biodiversity and Molecular Plant Breeding (CoE CroP-BioDiv), Svetošimunska cesta 25, HR-10000 Zagreb, Croatia

Phytocomponents in treatment of Alzheimer condition
Donika Hoxha*, Gjoshe Stefkov
Faculty of Pharmacy, Ss. Cyril and Methodius University, Mother Theresa 47, 1000 Skopje, North Macedonia

Richness of Specialized Metabolites in Veronica acinifolia L.  Hydrosols
Marija Nazlić*1, Dario Kremer 2, Karla Akrap1, Snježana Topić1, Valerija Dunkić1
1Faculty of Science, University of Split, Ruđera Boškovića 33, HR-21000 Split, Croatia
2Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, HR-10000 Zagreb, Croatia

Antioxidant potential and polyphenol content of five new cultivars of raspberries
Jovana Ljujić*1, Ivana Sofrenić1, Iris Đorđević2, Predrag Macura1, Vele Tešević1, Ljubodrag Vujisić1, Boban Anđelković1
1University of Belgrade – Faculty of Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia
2University of Belgrade – Faculty of Veterinary Medicine, Bulevar oslobođenja 16, 11000 Belgrade, Serbia

Microscopic analysis and the histochemical staining of three species from Asparagaceae family: Hosta plantaginea (Lam.) Asch., Ornithogalum umbellatum L. and Ornithogalum dubium Houtt.
Marin Ștefan-Claudiu*1, Hovaneț Marilena Viorica2, Robert Viorel Ancuceanu2, Mihaela Dinu2, Cristina Silvia Stoicescu3, Anghel Adriana-Iuliana2
1”Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Student, 6 Traian Vuia Street, 020956, Bucharest, Romania
2”Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmaceutical Botany and Cellular Biology Department, 6 Traian Vuia Street, 020956, Bucharest, Romania
3“Ilie Murgulescu” Institute of Physical Chemistry, Department of Chemical Thermodynamics, Spl. Independentei 202,P.O.Box. 12-194060021 Bucharest, Romania

Chemical composition, antioxidant and antimicrobial effect of Lavandula essential oil used as a natural antioxidant for cold-pressed oils
Sanja Kostadinović Veličkovska*1, Dejan Pljevljakušic2, Emilija Arsov1, Saša Mitrev1, Ljupčo Mihajlov1, Daniela Dimovska1
1Faculty of Agriculture, Goce Delčev University, Krste Misirkov bb, 2000 Štip, Republic of North Macedonia
2Institute for Medicinal Plants Research „Dr. Josif Pančić“, Tadeuša Košćuška 1, 11000 Belgrade, Republic of Serbia

Phenolic compound contents and antioxidant activity in different varieties of Hypericum perforatum L. collected from the Republic of North Macedonia
Elizabeta Markoska*1, Vlado Matevski1,2, Oliver Tusevski1, Sonja Gadzovska Simic1
1Laboratory of Plant Cell and Tissue Culture, Institute of Biology, Faculty of Natural Sciences and Mathematics, University „Ss. Cyril and Methodius“, Arhimedova 3, 1000 Skopje, Republic of North Macedonia
2Macedonian Academy of Sciences and Arts, Krste Misirkov 2, 1000 Skopje, Republic of North Macedonia

Contribution of phenolic acids and flavonols to the antioxidant activity of Hypericum perforatum L.
Ana Zhivkovikj*, Martina Trajkovska, Oliver Tusevski, Sonja Gadzovska Simic
Laboratory of Plant Cell and Tissue Culture, Institute of Biology, Faculty of Natural Sciences and Mathematics, University „Ss. Cyril and Methodius“, Arhimedova 3, 1000 Skopje, Republic of North Macedonia 

Phytochemical diversity of Rosa canina L. populations in Croatia
Martina Grdiša*1,2, Jana Šic Žlabur1, Filip Varga1,2, Patricija Bosilj1, Martina Skendrović-Babojelić1, Tatjana Klepo3, Zlatko Šatović1,2
1University of Zagreb Faculty of Agriculture, Svetošimunska cesta 25, 10000, Zagreb, Croatia
2Centre of Excellence for Biodiversity and Molecular Plant Breeding, Svetošimunska cesta 25, 10000, Zagreb, Croatia
3Croatian Agency for Agriculture and Food, Center of Pomology, Kralja Zvonimira 14a, 21210 Solin, Croatia

Morphological diversity of natural Dalmatian pyrethrum populations
Kim Klarin1, Filip Varga1,2, Ana Nimac2, Zlatko Šatović1,2, Martina Grdiša*1,2
1University of Zagreb Faculty of Agriculture, Department of Seed Science and Technology, Svetošimunska cesta 25, 10000, Zagreb, Croatia
2Centre of Excellence for Biodiversity and Molecular Plant Breeding, Svetošimunska cesta 25, 10000, Zagreb, Croatia

Effect of peptidomimetics nanofibers, as a carrier of silver on steviol glycoside content of micropropagated Stevia
Maria Geneva1, Mariana Sichanova1, Kamelia Miladinova-Georgieva1, Maria Petrova1, Elisaveta Kirova1, Victoria Ivanova1, Antoaneta Trendafilova*2
1Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Bldg. 21, 1113 Sofia, Bulgaria
2Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Bldg. 9, 1113 Sofia, Bulgaria

Oxidomics: A new approach to study the lipid oxidation and qualitative properties of cold-pressed vegetable oils
Sanja Kostadinović Veličkovska*1, Viktorija Maksimova2, Saša Mitrev1, Emilija Arsov1
1Faculty of Agriculture, Goce Delčev University, Krste Misirkov bb, 2000 Štip, Republic of North Macedonia
2Faculty of Medical Sciences, Goce Delčev University, Krste Misirkov bb, 2000 Štip, Republic of North Macedonia

Total phenolic, total flavonoid and anti-oxidant activity of methanolic extracts of some Centaurea species from Kosovo
Mimozë Buzhala*, Behxhet Mustafa, Bledar Pulaj, Avni Hajdari
Department of Biology, Faculty of Mathematical and Natural Science, University of Prishtina. Mother Theresa St. 10000 Prishtinë. Kosovo

Chemical composition of the essential oil of hops (Humulus lupulus L.) growing wild in Kosovo
Blerta Salihu*, Bexhet Mustafa, Bledar Pulaj, Avni Hajdari
1Department of Biology, Faculty of Mathematical and Natural Science, University of Prishtina “Hasan Prishtina”. Mother Theresa St. 10000 Prishtinë. Kosovo

Fractionation and antioxidant properties of Ammi visnaga umbels extracts
Zineb El Jabboury*1,2, Smail Aazza2, Zora Dajić Stevanović3, Stefan Kolašinac3, Ivan Šoštarić3, Meryem Benjelloun1, Lahsen El Ghadraoui1
1Laboratory of Functional Ecology and Environmental Engineering, Faculty of Science and Technology, University of Sidi Mohamed Ben Abdellah – Fez, Morocco
2Laboratory of Phytochemistry, National Agency of Medicinal and Aromatic Plants-Taounate, Morocco
3University of Belgrade, Faculty of Agriculture, Nemanjina 6, 11060 Belgrade, Serbia

New insights into sesquiterpene lactones composition of Western Balkan’s genus Amphoricarpos revealed by rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry
Milka Jadranin*1, Mirjana Cvetković1, Iris Đorđević2, Gordana Krstić3, Vele Tešević3, Slobodan Milosavljević3,4
1University of Belgrade – Institute of Chemistry, Technology, and Metallurgy, Department of Chemistry, Njegoševa 12, 11000 Belgrade, Serbia
2University of Belgrade – Faculty of Veterinary Medicine, Bulevar oslobođenja 18, 11000 Belgrade, Serbia
3University of Belgrade – Faculty of Chemistry, Studentski trg 12–16, 11000 Belgrade, Serbia
4Serbian Academy of Sciences and Arts, Kneza Mihaila 35, 11000 Belgrade, Serbia

Essential oil quality of peppermint clones established in cultivation in the village of Bavaniste (South Banat, Serbia)
Ana Stević1, Ljubiša Kolarić1, Andreja Komnenić2, Dejan Pljevljakušić*3 
1University of Belgrade, Faculty of Agriculture, Nemanjina 6, 11080 Belgrade, Serbia
2University of Montenegro, Biotechnical Faculty, Cetinjski put 2, 81000 Podgorica, Montenegro
3Institute for Medicinal Plants Research “Dr Josif Pančić”, Tadeuša Košćuška 1, 11000 Belgrade, Serbia

Evaluation of solvent efficiency for extraction of bioactive curcuminoids from turmeric (Curcuma longa L.)
Jana Klopchevska*1, Aleksandar Chadikovski1, Zoran Kavrakovski2, Marija Srbinoska3, Vesna Rafajlovska1
1Institute of Organic Technology, Faculty of Technology and Metallurgy, Ss. Cyril and Methodius University in Skopje,  Rudjer Boskovic 16, 1000 Skopje, Republic of North Macedonia
2Institute of Applied Chemistry and  Pharmaceutical Analysis, Faculty of Pharmacy, Mother Theresa 47, Ss. Cyril and Methodius University in Skopje 1000 Skopje, Republic of North Macedonia
3Scientific Tobacco Institute-Prilep, University “St. Kliment Ohridski”-Bitola, Kicevska bb, 7500 Prilep, Republic of North Macedonia

Comparison of mineral content between spontaneous and cultivated flowering stems of Sideritis scardica
Bujar Qazimi*1, Trajče Stafilov2, Katerina Bačeva-Andonovska3, Krsto Tašev4, Shpend Dragusha1, Hyrije Koraqi1, Vesel Qazimi5, Valon Ejupi1
1Faculty of Pharmacy, UBT- Higher Education Institution, Lagjia Kalabria, 10000 Prishtina, Republic of Kosovo
2Institute of Chemistry, Faculty of Natural Sciences and Mathematics, University Ss. Сyril and Methodius, 1000 Skopje, North Macedonia
3Research Center for Environment and Materials, Macedonian Academy of Sciences and Arts, Bul. Krste Misirkov 2, 1000 Skopje, North Macedonia
4State Phytosanitary Laboratory, Bul. Aleksandar Makedonski bb, 1000 Skopje, North Macedonia
5Medical High School, “Nikola Shtejn”, Ilinden street. N.n., 1200 Tetovo, North Macedonia

Total polyphenols and flavonoids in Macedonian Oriental tobacco
Marija Srbinoska*1, Jana Klopchevska2, Aleksandar Chadikovski2,  Zoran Kavrakovski3, Vesna Rafajlovska2
1Scientific Tobacco Institute-Prilep, University “St. Kliment Ohridski”-Bitola, Kicevska bb, 7500 Prilep, Republic of North Macedonia
2Institute of Organic Technology, Faculty of Technology and Metallurgy, Ss. Cyril and Methodius University in Skopje,  Rudjer Boskovic 16, 1000 Skopje, Republic of North Macedonia
3Institute of Applied Chemistry and  Pharmaceutical Analysis, Faculty of Pharmacy, Mother Theresa 47, Ss. Cyril and Methodius University in Skopje 1000 Skopje, Republic of North Macedonia

Chemical composition and antioxidant properties of Juniperus communis L. commercial essential oils from two regions in North Macedonia
Vedrana Bojkovska*, Marija Karapandzova, Veronika Stoilkovska Gjorgievska, Svetlana Kulevanova, Gjoshe Stefkov, Ivana Cvetkovikj Karanfilova
Institute of Pharmacognosy, Faculty of Pharmacy, “Ss Cyril and Methodius” University in Skopje, Majka Tereza 47, 1000 Skopje, Republic of North Macedonia

Antimicrobial activity of ethyl acetate extract of an endemic Centaurea glaberrima Tausch (Asteraceae)
Milica Miletić*1, Marija Ivanov2, Jelica Novaković1, Pedja Janaćković1
1University of Belgrade – Faculty of Biology, Department of Morphology and Systematics of Plants, Studentski trg 16, 11000 Belgrade, Serbia
2Department of Plant Physiology, Institute for Biological Research “Siniša Stanković”, National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11000 Belgrade, Serbia

Phenolic profile and antifungal activity of leaf extract of Artemisia absinthium L. (Asteraceae)
Maja Radulović*1, Milan Gavrilović1, Uroš Gašić2, Nikola Unković1, Pedja Janaćković1
1Faculty of Biology, University of Belgrade, Studentski trg 16, 11000, Belgrade, Serbia
2Institute for Biological Research “Siniša Stanković” – National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060, Belgrade, Serbia

Phytochemical screening of the olive variety ‘Istrska Belica’ infected by fungus Venturia oleaginea
Pedja Janaćković*1, Uroš Gašić2, Milan Gavrilović1, Ivica Dimkić1, Matjaž Hladnik3, Alenka Baruca Arbeiter3, Dunja Bandelj3
1University of Belgrade – Faculty of Biology,  Studentski trg 16, 11000 Belgrade, Serbia
2Institute for Biological Research “Siniša Stanković” – National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060, Belgrade, Serbia
3University of Primorska, Faculty of Mathematics, Natural Sciences and Information Technologies (FAMNIT), Glagoljaška 8, Sl-6000 Koper, Slovenia

Salix alba phytoremediation potential of heavy metals
Demush Bajraktari1, Lulzim Zeneli2, Biljana Bauer*3
1Faculty of Pharmacy, UBT Higher Education Institution, LagjjaKalabria, p.n. 10000 Prishtine, Kosovo
2Faculty of Education, University “Fehmi Agani”, Str. “Ismail Qemali”, n.n., 50 000, Gjakova, Kosovo
3Faculty of Pharmacy, Ss. Cyril and Methodius, University of Skopje, “Majka Tereza” No. 47, 1000, Skopje, North Macedonia

Raman spectroscopy analysis of rosehip herbal teas
Ilinka Pećinar1, Stefan Kolašinac*1, Dragana Rančić1, Ivan Šoštarić1, Zora Dajić-Stevanović1
1University of Belgrade, Faculty of Agriculture, Nemanjina 6, 11080 Belgrade, Republic of Serbia

Conservation of European Biodiversity through Exploitation of Traditional Herbal Knowledge for the Development of Innovative Products.
Konstantia Graikou*1, Nikolaos Fokialakis1, Vladimir Dimitrov2, Zora Dajic3, Anna Rita Bilia4, Jelena Zivkovic5, Alberto Dias6, Konstantinos Kasiotis7, Antreas Afantitis8, Konstantinos Gardikis9, Mirko Oluški10, Juan Ramón Muñoz Montaño11, Nektarios Aligiannis1
1Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771, Athens, Greece
2Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. Georgi Bonchev 9, 1113, Sofia, Bulgaria.
3Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11080, Belgrade, Serbia.
4Department of Chemistry “Ugo Schiff”, University of Florence, Piazza San Marco 4, 50121, Florence, Italy.
5Institute for Medicinal Plants Research “Dr Josif Pančić”, Tadeuša Košćuška 1, 171000, Belgrade, Serbia.
6Department of Biology and CITAB-UM research Center, University of Minho, Largo do Paço, 4704-553, Braga, Portugal.
7Benaki Phytopathological Institute, Stefanou Delta street 8, 14561, Athens, Greece.
8Novamechanics Ltd, Prigkipissis Nte Tyras 16 Karantoki Building, 1065, Nicosia, Cyprus.
9Apivita SA, Industrial park of Markopoulo, 19003, Athens, Greece.
10Euro Herbs d.o.o., Lovćenska 7, 21000, Novi Sad, Serbia.
11Zurko Research SL, Calle Gran via 62, 4 Izq, 28013, Madrid, Spain.

Hellenoinos: NMR and LC-MS metabolic profiling of grape skin extracts of six Greek grape varieties
Adamantia-Eleni Manola1, Antigoni Cheilari*1, Yorgos Kotseridis2, Nektarios Aligiannis1
1Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771, Greece
2Department of Oenology, Faculty of Food Science & Human Nutrition, Agricultural University of Athens, 75 Iera Odos, Athens 11855, Greece

SECTION 2 – 360° CANNABIS

Legal approaches for application of cannabis-based preparations in Europe
Emilija Nikolovska*1, Zorica Naumovska2, Zoran Sterjev2, Gjoshe Stefkov2
1Regulatory Affairs Department, Rifam DOO, St.1551 No.10, 1000 Skopje, Republic of North Macedonia
2Ss. Cyril and Methodius University, Majka Tereza 47, 1000 Skopje, Republic of North Macedonia 

Quality requirements for Cannabis flos as final product
Magdalena Hristova*, Bistra Angelovska
Faculty of medical sciences, University Goce Delcev, Krste Misirkov 10-A, 2000 Stip, N. Macedonia

Individual Approach in Achieving Optimal Balance of THC and CBD in Supplementary Treatment of Neurological Diseases
Gordana Trendovska Serafimovska
HAPA PHARM,  Blvd. “8mi Septemvri”2-2, 1000, Skopje, N. Macedonia

Basic Recommendations for Creation of Dosage Schedule of Cannabis-based Products based on Benefit / Side Effects Ratio in Supplementary Treatment of Malignant Diseases
Gordana Trendovska Serafimovska*
HAPA PHARM,  Blvd. “8mi Septemvri”2-2, 1000, Skopje, N. Macedonia

Comparation of different methods for determination of Cannabis inflorescences humidity
Iskra Davkova*, Nadica Trajkovska, Ivana Cvetkovikj Karanfilova, Ana Trajkovska, Gjoshe Stefkov, Svetlana Kulevanova, Marija Karapandzova
Ss Cyril and Methodius University in Skopje, Faculty of Pharmacy, Institute of Pharmacognosy, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia

Antimicrobial properties of Cannabis Sativa L. plant
Slavica Dinusheva*, Aleksandra Pecova
Sinceritas AD Skopje, Anton Panov 11, 1000 Skopje, North Macedonia   

Development and validation of analytical method for microbiological quality control of  Cannabis oil solution: THC 40 mg + CBD 40 mg/1 ml
Marjan Velkovski*, Damjan Shushleski, Irena Slaveska Spirevska, Elena Metcheva, Silvana Ristevska, Ivana Karchicka
Replek Farm, st. Kozle 188, 1000, Skopje, N. Macedonia

Comprehensive methodology for characterization of Cannabis sativa L. (hemp) inflorescences through combined NMR and LC-based metabolite profiling
Petros S. Tzimas1, Eleftherios A. Petrakis1, Stavros Beteinakis1, Panayiota Papastylianou2, Ioanna Kakabouki2, Daphne Chandrinou3, Andrea L. Small-Howard4, Dimitrios Bilalis2, Maria Halabalaki1, Leandros A. Skaltsounis*1
1Division of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupoli Zografou, 15771 Athens, Greece
2Laboratory of Agronomy, Department of Crop Science, Agricultural University of Athens, 75 Iera Odos Str., 11855 Athens, Greece
3PharmaGnose S.A, Athens, Greece
4GbS Global Biopharma, Ottawa, Canada

Post marketing surveillance of cannabis-based preparations
Ivana Josifovska1, Gjoshe Stefkov2, Ivana Cvetkovikj Karanfilova2, Aleksandra K. Nestorovska3, Aleksandra Grozdanova3, Zoran Sterjev3, Zorica Naumovska3
1Varus DOOEL, Faculty of Pharmacy, University “Ss. Cyril and Methodius”, North Macedonia
2Institute of Pharmacognosy, Faculty of Pharmacy, University “Ss. Cyril and Methodius”, Majka Tereza 47, 1000 Skopje, Republic of N. Macedonia
3Institute of Pharmaceutical chemistry, Faculty of Pharmacy, University “Ss. Cyril and Methodius”, Majka Tereza 47, 1000 Skopje, Republic of N. Macedonia

Regulation on pesticide residues use and testing in cannabis and cannabis-based products in North and South America]
Milka Ljoncheva1, Ivana Cvetkovikj Karanfilova*2, Gjoshe Stefkov2
1Jožef Stefan International Postgraduate School, Jamova cesta 39, 1000 Ljubljana, Slovenia
2Institute of Pharmacognosy, Faculty of Pharmacy, University Cc. Cyril and Methodius, Mother Tereza 47, 1000 Skopje, North Macedonia

Analysis of hypoglycemic effects of cannabidiol following oral and intraperitoneal administration in healthy rats
Elona Djemaili*1, Elena Rafailovska2, Aleksandar Dimkovski 3, Evgenija Mihajloska3, Zorica Naumovska3, Gjose Stefkov3, Biljana Miova2, Ljubica Suturkova3
1Department of Pharmacy, Faculty of Medical Sciences, University of Tetova, Ilinden bb, 1200 Tetovo, R.N. Macedonia
2Department of Physiology and Biochemistry, Institute of Biology, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University in Skopje, Arhimedova 3, 1000 Skopje, R.N. Macedonia.
3Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje,  Mother Tereza 47, 1000 Skopje, R.N. Macedonia

SECTION 3 – PHARMACOLOGY AND PHYTOTHERAPY (BIOACTIVITY, TOXICITY, ETNOPHARMACOLOGY AND ETNOBOTANY)

Dioscorides’ recipes in two Croatian books of folk recipes
Suzana Inić, Petra Gašparac, Marijana Zovko Končić
University of Zagreb Faculty of Pharmacy and Biochemistry, Ante Kovačića 1, 10000 Zagreb, Croatia

Modulation of adipogenesis by Polygonum hydropiper L. and P. aviculare L. extracts
Martina Savova*1,2, Apostol Apostolov1,2,3, Liliya Mihaylova1,2, Milen Georgiev1,2
1Department of Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria
2Laboratory of Metabolomics, Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd, 4000 Plovdiv, Bulgaria
3Department of Plant Physiology and Molecular Biology, University of Plovdiv, 24 Tzar Assen, 4000 Plovdiv, Bulgaria 

Orlistat decreases lipid accumulation and affects expression of genes related to lipid metabolism in Caenorhabditis elegans
Apostol Apostolov1,2,3, Martina Savova1,2, Monika Todorova*1,2, Galina Yahubyan3, Milen I. Georgiev1,2
1Department of Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria
2Laboratory of Metabolomics, Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv, Bulgaria
3Department of Plant Physiology and Molecular Biology, University of Plovdiv, 24 Tzar Assen Str., 4000 Plovdiv, Bulgaria 

Discovery of bioactive natural products with skin beneficial properties through the exploitation of ethnobotanical studies conducted in the Balkans
Efthymia Eleni Tsioutsiou*, Antigoni Cheilari, Nektarios Aligiannis
Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771, Greece 

PPARγ inhibition mediates Alchemilla monticola Opiz anti-adipogenic effect in human adipocytes
Liliya Mihaylova*1,2*, Saveta Mladenova3, Martina Savova1,2, Zhivka Balcheva-Sivenova2, Andrey Marchev2, Milen I. Georgiev1,2
1Department of Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria
2Laboratory of Metabolomics, Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd, 4000 Plovdiv, Bulgaria
3BB-NCIPD Ltd., National Center of Infectious and Parasitic Diseases, Ministry of Health, Sofia, Bulgaria

Pharmacovigilance of herbal and traditional herbal medicines
Elena Mladenovska1, Zorica Naumovska2, Zoran Sterjev2, Ivana Cvetkovikj Karanfilova3, Aleksandra K. Nestorovska2, Gjoshe Stefkov3
1Euro-farm Skopje, Faculty of Pharmacy, University “Ss. Cyril and Methodius”, North Macedonia
2Institute of Pharmaceutical chemistry, Faculty of Pharmacy, University “Ss. Cyril and Methodius”, Majka Tereza 47, 1000 Skopje, North Macedonia
3Institute of Pharmacognosy, Faculty of Pharmacy, University “Ss. Cyril and Methodius”, Majka Tereza 47, 1000 Skopje, North Macedonia

ANASA – Development of bioactive herbal extracts to treat severe acute respiratory system diseases
Evanthia Dina1, Dimitrios Toumpanakis2, Antigoni Cheilari*1, Athanasia Chatzianastasiou2, Konstantinos Salagiannis3, Sotiris Vasiliadis4, Diamanti Ioanna5, George Naoum6, Andreas Papapetropoulos3,7, Theodoros Vassilakopoulos2,8, Nektarios Aligiannis1
1Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771, Greece
2“Marianthi Simou” Applied Biomedical Research and Training Center, Evangelismos Hospital Medical School, National and Kapodistrian University of Athens, Greece.
3Clinical, Experimental Surgery and Translational Research Center, Biomedical Research  Foundation of the Academy of Athens, Greece.
4Aromafarms LP, Smila, Karoutes, 27065, Ancient Olympia, Greece
5Pellas Nature S.A, Seremes, Proastio, 58200, Edessa, Greece
6Naumed, 25 Martiou, 42100, Trikala, Greece
7Laboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
8Physiology Department, Medical School, National and Kapodistrian University of Athens, Greece

Ex situ conservation and comparative determination of antimicrobial activity of endemic species from genus Stachys
Desislava Mantovska1*, Detelina Petrova1, Lyubomira Yocheva2, Zhenya Yordanova1
1Department of Plant Physiology, Faculty of Biology, Sofia University “St. Kliment Ohridski”, Sofia, Bulgaria
2Department of Biology, medicinal genetics and microbiology, Faculty of Medicine, Sofia University, “St. Kliment Ohridski”, Sofia, Bulgaria

Olive oil and olive leaf extracts consumption: A survey on consumer’s attitudes
Jelena Purić1, Dubravka Bigović*2, Katarina Šavikin2, Jelena Živković2, Milan Ilić1
1Faculty of Pharmacy, University of the Academy of Commerce, Trg mladenaca 5, 21101 Novi Sad, Srbija
2Institute for Medicinal Plants Research “Dr Josif Pančić”, Tadeuša Košćuška 1, 11000 Belgrade, Serbia

Inhibition of glioblastoma growth by Rhodiola rosea L. and its active constituents: An in vitro and in vivo study
Andrey S. Marchev1, Iliyan K. Manoylov2, Gabriela V. Boneva2, Silviya L. Bradyanova2, Ivanka K. Koycheva1, Andrey I. Tchorbanov2, Milen I. Georgiev1
1Laboratory of Metabolomics, Department of Biotechnology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd, 4000 Plovdiv, Bulgaria
2Laboratory of Experimental Immunology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 26 Georgi Bonchev Str., 1113 Sofia, Bulgaria

Traditional use of cultivated plants in Mt. Tara (Western Serbia) – an ethnobotanical survey
Milan Gavrilović*1, Milica Milutinović1, Zora Dajić Stevanović2, Pedja Janaćković1
1University of Belgrade, Faculty of Biology, Department of Morphology and Systematics of Plants, Studentski trg 16, 11000 Belgrade, Serbia
2University of Belgrade, Faculty of Agriculture, Department of Agrobotany, Nemanjina 6, 11080 Belgrade, Serbia

In vitro Anti-proliferative Effect of Some Asparagus Taxa on Colon Cancer Cell Lines
Saltan Iscan, G.*1, Karacaoglu, M.1,2, Ileri Ozler, H.K.1,2, Cansaran Duman, D3
1Ankara University, Faculty of Pharmacy, Department of Pharmacognosy, 06560, Ankara, Turkey
2Ankara University Graduate School of Health Sciences, 06110, Ankara, Turkey
3Ankara University, Biotechnology Institute, 06135, Ankara, Turkey

Identification of anti-epileptic natural products using zebrafish
Alexander D. Crawford*1,2
1Department of Preclinical Sciences and Pathology, Norwegian University of Life Sciences (NMBU), Elizabeth Stephansens vei 15, 1430 Ås, Norway
2Institute for Orphan Drug Discovery, Bremerhavener Innovations- und Gründerzentrum (BRIG), Stresemannstraße 46, 27570 Bremerhaven, Germany

Traditional approach in prevention and treatment of COVID-19 in Republic of North Macedonia
Biljana Bauer
Faculty of Pharmacy, University of Ss Cyril and Methodius, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia

Traditional knowledge on use of medicinal plants in Central Balkans for treating eczema
Ivan Šoštarić, Sofija Kilibarda, Stefan Kolašinac, Svetlana Aćić, Zora Dajić Stevanović
Universsity of Belgrade, Faculty of Agriculture, Nemanjina 6, 11080 Belgrade, Serbia

Antioxidant potential of Hypericum perforatum L. hairy roots extracts in the kidney of STZ-induced diabetic rats
Elena Rafailovska1, Cvetanka Trifunovska1, Oliver Tushevski2, Sonja Gadzovska- Simic2, Suzana Dinevska- Kjovkarovska1, Biljana Miova*1
1Department of Physiology and Biochemistry, Institute of Biology, Faculty of Natural Sciences and Mathematics “Ss Cyril and Methodius” University, 100 Skopje, North Macedonia
2Laboratory of Plant Cell and Tissue Culture, Institute of Biology, Faculty of Natural Sciences and Mathematics “Ss Cyril and Methodius” University, 100 Skopje, North Macedonia

Comparative analysis of peel extract and juice obtained from wild and cultivated pomegranate fruits
Milica Radan*, Zorana Mutavski, Katarina Šavikin, Teodora Janković, Gordana Zdunić, Jelena Živković, Nemanja Krgović, Snežana Kuzmanović-Nedeljković 
Institute for Medicinal Plants Research “Dr Josif Pančić”, Tadeuša Košćuška 1, 11000 Belgrade, Serbia

Use of Hypericum perforatum as food supplement
Angela Ristevski*1, Riste Ristevski2, Elena Jurukovska3, Slavica Jurukovska4, Lidija Petrusevska-Tozi5
1Bayer d.o.o Ljubljana representative office 1000 Skopje, North Macedonia
²Eurofarm doel, 1000 Skopje, North Macedonia
³Ewopharma АG representative office 1000 Skopje, North Macedonia
⁴PHI Health centar1000 Skopje, North Macedonia
⁵Faculty of Pharmacy, “Ss Cyril and Methodius” University in Skopje, Majka Tereza 47, 1000 Skopje, Republic of North Macedonia

Photoprotective properties of myconoside, isolated from Haberlea rhodopensis, under UVA/UVB-induced cytotoxicity in HaCaT cells
Iva Stoykova*1,2, Ivanka Koycheva1,2, Biser Binev1,2, Milen I. Georgiev1,2
1Center of Plant System Biology and Biotechnology, 4000 Plovdiv, Bulgaria
2Laboratory of Metabolomics, Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd, 4000 Plovdiv, Bulgaria

Modulation of Nrf2 expression in human neutrophils by Ballota nigra extract
Kristiana Amirova1,2, Petya Dimitrova3, Ivanka Koycheva*1,2, Jivka Balcheva-Sivenova1,2, Milen I. Georgiev1,2
1Department of Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria
2Laboratory of Metabolomics, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd, 4000 Plovdiv, Bulgaria
3Department of Immunology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 26 Georgi Bonchev Str., 1113 Sofia, Bulgaria 

Exploitation of ethnopharmacological data towards the discovery of novel wound healing agents
Argyro Vontzalidou*, Efthymia Eleni Tsioutsiou, Evanthia Dina, Antigoni Cheilari, Nektarios Aligiannis
Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771, Greece

SECTION 4 – PRODUCTION OF HERBAL SUBSTANCES AND PREPARATIONS (CULTIVATION, BREEDING, BIOTECHNOLOGY AND PROCESSING)

Soilless propagation of wild Ericaceae medicinal shrubs
Marina Stanilova*, Boryanka Traykova, Irena Mincheva, Elina Yankova-Tsvetkova
Institute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences, Department of Plant and Fungal Diversity and Resources, 23 Acad. G. Bonchev str., 1113 Sofia, Bulgaria

Evaluation of the antioxidant activity of micropropagated stevia affected by peptidomimetic nanofibers as an Ag carrier
Mariana Sichanova1, Kamelia Miladinova-Georgieva1, Maria Petrova1, Elisaveta Kirova1, Daniela Tsecova2, Maria Geneva1
1Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Bldg. 21, 1113 Sofia, Bulgaria
2Department of Organic Chemistry, University of Chemical Technology and Metallurgy, 8“St. Kl.Ohridski” Blvd, Sofia 1756, Bulgaria  

Flavonoids productivity of wild growing and in vitro cultivated Hypricum species
Antoaneta Trendafilova1, Viktoriya Ivanova1, Ina Aneva2, Kalina Danova*1
1Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
2Institute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria